TMRC Facilities, Instruments & Activities
TMRC Facilities, Instruments & Activities
TMRC offers a comprehensive, end-to-end in vitro research ecosystem supporting discovery, validation, and mechanistic understanding under one integrated framework.
In Vitro Non-Biological Testing Laboratory (TMRC-701)
TMRC-701 is a high-end analytical and formulation facility supporting pharmaceutical sciences, nanotechnology, materials science, and chemical analysis.
Core Capabilities
- Design and development of advanced nano- and micro-formulations using diverse biopolymers
- Particle size distribution, stability profiling, and physicochemical characterization
- High-resolution chemical, structural, and thermal analyses
- Phytoconstituent profiling, impurity assessment, pesticide detection, and ultra-trace quantification
Key Instrumentation
- Waters Xevo TQ-XS Tandem Quadrupole Mass Spectrometer (ultra-trace analysis)
- Automated and Manual HPLC Systems
- Flash Chromatography System
- Nano Generator (Precigenome, USA)
- Particle Size Analyzer
- FTIR and UV-Visible Spectrophotometers
- Differential Scanning Calorimeter (DSC)
- Freeze Dryer
Technical Support: Mr. Mohammad Quamrul Islam, Ms. Aida Ruzzana Binti Ghafar
In Vitro Biological Testing Laboratory (TMRC-709)
TMRC-709 functions as a multidisciplinary translational research hub integrating biological, molecular, and omics platforms within a single, cohesive environment.
Microbiology Unit
- Repository of bacterial and fungal strains
- Antimicrobial susceptibility and microbial interaction studies
- Biocompatibility assessment of novel compounds and biomaterials
Cell Culture Unit
- Extensive panel of human and murine normal, cancer, and primary cell lines
- Cancer models: breast, lung, cervical, hepatic, and colorectal
- Normal and primary cells including epithelial, fibroblast, and stem cell systems
- Cytotoxicity, mechanistic, pathway-based, and therapeutic screening
Molecular Biology Unit
- RT-PCR and qRT-PCR platforms for qualitative and quantitative gene expression analysis
- Nucleic acid extraction, quantification, and electrophoretic workflows
- Evaluation of molecular signaling pathways and target modulation
Next Generation Sequencing (NGS) Unit
- MinION Mk1D Nanopore Sequencing System
- MiniSeq (Illumina) short-read sequencing platform
- PromethION Solo: large-scale long-read DNA and RNA sequencing
- In-house whole genome sequencing, transcriptomics, epigenetics, and structural variant analysis
- Dedicated sequencing and bioinformatics support under defined frameworks
Biochemistry & Immunology Unit
- Fully automated biochemistry analyzer supporting 95+ test parameters
- Comprehensive metabolic, inflammatory, immunological, and biomarker panels
- ELISA-based quantitative biomarker estimation
- Body mass composition analysis
Histopathology Unit
- Automated tissue processing and embedding systems
- Microtome and high-resolution digital microscopy
- Routine and special stains including H&E and Masson’s Trichrome
Technical Support: Ms. Sheela Haridas, Mr. Michael V. Magaogao, Ms. Shatha Nayef Mahd Abdel Jaber
Activities
- High-impact translational research projects
- Drug discovery and target validation studies
- Biomarker discovery and diagnostic research
- Skill-based training programs and workshops
- National and international collaborative research initiatives