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Dr. Ashfaque Hossain Profile Picture

Dr. Ashfaque Hossain

Deputy Director - Research & Professor - Medical Microbiology & Immunology

  • ashfaque@rakmhsu.ac.ae
Educational Qualification
  • PhD (Microbiology) 1990, University of Glasgow, UK
  • MSc (Microbiology) 1984, University of Dhaka, Bangladesh
  • BSc (Biochemistry) 1982, University of Dhaka, Bangladesh
Professional Career
  • More than 20 years of teaching and research experience (Bangladesh, UK, USA, Saudi Arabia and UAE).
  • Experience in study guide and course curriculum preparation, course coordination; Supervision of research of M.S. and MBBS students.
  • Technology development: US patent no. 8062845. Life Technologies (an USA Biotechnology Company) adopted the technology to develop a research kit TRIZOl-MAX for RNA analysis which is marketed globally.
  • Broad multidisciplinary research experience (microbiology, molecular biology, virology, immunology).
  • More than 40 publications in peer reviewed microbiology, virology and immunology journals (33 research papers in journals published with ISI impact factors ranging from 0.33 to 5.95; Total citation 1471; h-index 14 (source: Google Scholar). Cumulative ISI impact factor 96.1; International conference abstracts-35; Book Chapters-2.
  • August, 2016-Present: Professor and Chairperson. Department of Medical Microbiology and Immunology. RAK Medical and Health Sciences University, Ras Al Khaimah, UAE.
  • September, 2013-August, 2016. Associate Professor of Medical Microbiology, College of Medicine, University of Hail, Hail, Saudi Arabia.
  • September, 2008-August, 2013. Assistant Professor of Medical Microbiology, College of Medicine, University of Hail, Hail, Saudi Arabia.
  • July, 2000-September, 2008. Senior Scientist, Molecular Biology and Research Assistant Professor. Creighton University School of Medicine, Omaha, NE, USA
  • August, 1998-June, 2000. Postdoctoral Research Fellow. Department of Pathology, Harvard Medical School, Boston, MA, USA.
  • September, 1996- August, 1998. Research Scientist. Avant Immunotherapeutics. Boston, MA, USA.
  • April. 1993-September, 1996. Postdoctoral Research Fellow and Teaching Assistant, Department of Biomedical Sciences. University of Nebraska, Lincoln, NE, USA.
  • January, 1990-April, 1993. Assistant Professor, Department of Microbiology, University of Dhaka, Bangladesh.
  • September, 1985-December, 1989. Commonwealth PhD Research Fellow and Teaching Assistant. Department of Microbiology, University of Glasgow, UK.
  • June, 1884-August, 1985. Research Officer, Enteric Pathogen Division, International Center for Diarrheal Disease Research (icddr), Bangladesh.
Achievements/ Interests/Publications/Awards
  • Talukdar, P. K., Udompijitkul, P., Hossain, A. and Sarker, M. (2017). Inactivation strategies for Clostridium perfringens spores and vegetative cells. Applied and Environmental Microbiology. 83: piie02731-16. PMID: 27795314.
  • Alshaya, H. K., Alogla, S. A., Alshammari, K. S., Nazareno, C. L. AlJameel, M. A. S. and Hossain, A. (2016). Isolation and characterization of bacterial species from patients with dental caries and caries-free health subjects. Journal of Pharmaceutical and Biomedical Sciences 6: 333-337.
  • Hossain, A., Menezes, G., Al-Mogbel, M. and Ashankyty, I. (2016). Modulation of environmental toxicants and therapeutic agents by gut microbiome. Book chapter in Microbiome and Toxicology. Taylor and Francis Publications, Boca Raton, Florida, USA.
  • Nawaf Raja R. Alshammari, Samir Qiblawi, Mamoun Shadeed and Ashfaque Hossain (2016). Synergistic antimicrobial activity of aqueous extract of Date Palm (Phoenix dactylifera) and almond (Prunus dulcis) with amoxicillin against Pseudomonas aeruginosa and Acinetobacter baumannii. Journal of Pure and Applied Microbiology. 10:1037-1041.
  • Mahbuba Ashrafi Mumu, M Tahminur Rahman, Ashfaque Hossain, Sayera Banu, Muhammad Manjurul Karim. (2016). Tuberculous prostatitis is rare in prostate cancer patients in BangladeshBioresearch Communications. 1: 281-284.
  • Hosen, M. B., Salam, M. A., Islam, M. F., Hossain, A., Hawlader, M. Z. H and Kabir, Y. (2015). Association of p53 gene polymorphisms with susceptibility of bladder cancer in Bangladeshi population. Tumor Biology DOI 10.1007/s13277-015-3324-3.
  • Al-Mogbel, S. M., Khan, M., Shadeed, M., Harahsha, M. and Hossain, A. (2015). Influence of growth in biofilm in the formation of new biofilm by clinical isolates of Acinetobacter baumannii. Journal of Pure and Applied Microbiology 9: 413-416.
  • Hossain, A., Akhtar, S. and Kabir, Y. (2015). Diet, microbiome and human health. Book chapter on health benefits of fermented foods. Taylor and Francis Publications, Boca Raton, Florida, USA.
  • Akhtar, S., Sarker, M.R, and , Hossain, A. (2014). Microbiological food safety: A dilemma of developing societies. Critical Reviews in Microbiology. 10:1-14.
  • Shadeed, M., AlMogbel, M. S., Al-Hazimi, A. and Hossain, A. (2014). Influence of Normal Human Serum on Production of Biofilm by Acinetobacter baumannii. Journal of Pure and Applied Microbiology. 8: 273-278.
  • Hossain, A. (2013). Growth in biofilm enhances potential to form new biofilm by Pseudomonas aeruginosa. Life Science Journal. 10:356-359.
  • Hossain, A. (2013) Biofilm Infections: A New Therapeutic Challenge. International Journal of Pharmaceutical Sciences and Research. 4: 3286-3295.
  • Hossain, A. (2013). Influence of normal human serum on production of biofilm by clinical isolates of Pseudomonas aeruginosa. Life Science Journal. 10:151-154.
  • Kiblawi, S., Hazimi, A., AlMogbel, M S., Hossain, A. and Bagchi, D. and (2012). Chemopreventive effects of cardamom (Elettaria cardamomum L) on chemically induced skin carcinogenesis in Swiss albino mice. Journal of Medicinal Foods. 15: 576-580.
  • Hossain, A. and Jung, L.K. (2008). Differential expression of bone specific alkaline phospahtase in human B cells. Cellular Immunology. 253: 66-70.
  • Hong, S.G. Moland, E.S., Wickman, P., Black, J.A. Hossain, A. Hanson, N.D. and Thomson (2007). In vitro studies with DQ-113 and comparison fluoroquinololes to determine propensities to selected resistance in Gram-positive cocci. Antimicrobial Agents and Chemotherapy. 51: 1512-1514.
  • Moland, E.S., Moland, E.S., Hanson, N.D., Black, J.A. Hossain, A. Song, W. and Thomson, K.S (2006). Prevalence of newer ?-lactamases in Gram- negative clinical isolates collected in the in United States from 2001 to 2002. Journal of Clinical Microbiology. 44: 3318-3324.
  • Hanson, N.D., Hossain, A. Buck, A. Moland, E.S. and Thomson, K.S. (2006).The First Occurrence of a Pseudomonas aeruginosa in the United States Producing an IMP Metallo-?-lactamase, IMP-18. Antimicrobial Agents and Chemotherapy. 50: 1272-2273.
  • Hossain, A, Ferraro, M. J., Pino. R. M., Dew, R. B. III, Moland, E.S., Lockhart, T. J., Thomson, K. S. Goering, R. V. and Hanson, N.D. (2004) Plasmid-mediated Carbapenem hydrolyzing enzyme, KPC-2, in Enterobacter sp. 48: 4438-4440.
  • Hossain, A. Reisbig, M.D. and Hanson, N.D. (2004). Plasmid-encoded functions compensate for the biological cost of AmpC over-expression in a clinical isolate of Salmonella typhimurium. Journal of Antimicrobial Chemotherapy 53: 964-970.
  • Pitout, J.D.D., Hossain, A. and Hanson, N.D. (2004). Phenotypic and molecular detection of CTX-M-? lactamases produced by Escherichia coli and Klebsiella spp. Journal of Clinical Microbiology 42: 5715-5721.
  • Moland, E.S., Black, J.A., Hossain, A., Hanson, N.D., Thomson, K.S. and Pottumarthy, S. (2003). Discovery of CTX-M like ESBLs in E. coli isolates from five states in the USA. Antimicrobial Agents and Chemotherapy. 47: 2382-2383.
  • Moland, E. S., Hanson, N. D., Herrera, V., Black, J., Lockhart, T. J., Hossain, A., Johnson, J. Goering, R. and Thomson, K.S (2003). Plasmid-mediated carbapenem-hydrolyzing ?-lactamase, KPC-2, in Klebsiella pneumoniae isolates. Journal of Antimicrobial Chemotherapy. 51: 711-714.
  • Hanson, N.D., Moland, E.S., Hossain, A. Neville, S.A.,Gosbell, I.B., and Thompson, K.S. (2002). Salmonella enterica serotype Typhimurium producing CMY-7, SHV-9 and OXA-30 b-lactamases. Journal of Antimicrobial Chemotherapy. 49: 1011-1014.
  • Jiang, Y., Hossain, A., Winkler, M. T., Holt, T., Doster, A. and Jones, C. (1998). A protein encoded by the latency-related gene of bovine herpes virus 1 is expressed in trigeminal ganglionic neuron of latently infected cattle and interacts with cyclin dependent kinase 2 during productive infection. Journal of Virology. 72: 8133-8142.
  • Hossain, A., Holt, T. Zanella, J. and Jones, C. (1997). Analysis of cyclin dependent kinase activity after herpes simplex virus type 2 infection. Journal of General Virology 78: 3341-3346.
  • Schang, L. M., Hossain, A. and Jones, C. (1996). The latency-related gene of bovine herpesvirus 1 encodes a product which inhibits cell cycle progression. Journal of Virology. 70:3807-3814
  • Parvis, A., Majibur, R., Bhuiyan, S. H. Arifur, R., and Hossain, A. (1996). Acid sensitivity as affected by physico-chemical stresses in Aeromononas hydrophila. Japanese Journal of Medical Science and Biology. 49: 95-102.
  • Hossain, A., Schang, L. and Jones, C. (1995). Identification of gene products synthesized from the latency related gene of bovine herpes virus 1. Journal of Virology. 69: 5345-5352.
  • Hossain, A., Freer, J.H. and Stewart-Tull, D.E.S. (1993). Heat-labile and heat-stable toxins of Campylobacter jejuni. FEMS Medical Microbiology and Immunology. 6: 331-340.
  • Haider, K., Hossain, A., Wanke, C., Qadri, F. and Nahar, N. (1993). Production of mucinase and neuraminidase and binding of Shigella spp. to intestinal mucin. Journal of Diarrheal Disease Research. 11: 88-92.
  • Ali, A., Unicomb, L., Bingnan, F. and Hossain, A. (1993). Molecular heterogeneity of human group A Rota virus in rural Bangladesh as determined by electrophoresis of genomic ribonucleic acid. Tropical Medicine. 35: 53-63.
  • Ali, A., Unicomb, L., Bingnan, F. and Hossain, A. (1993). Determination of single hybridization temperature of serotyping of human group A Rota virus with oligonucleotide probes. Tropical Medicine. 35: 119-124.
  • Ali, A., Bingnan, F. Unicomb, L., Rahim, Z. Hossain, A. and Tzipori, S. (1993). Evaluation of a probe hybridization serotyping method for Rota Virus. Journal of Diarrheal Disease Research. 11: 153-156.
  • Haider, K. Faruque, S.M., Albert, M. J. and Hossain, A. (1992). Comparison of modified adherence assay with existing assay methods for identification of enteroaggregative Escherichia coli. Journal of Clinical Microbiology. 30: 1614-1616.
  • Haider, K., Albert, M. J., Hossain, A. and Nahar, S. (1991). Contact hemolysin production by enteroinvasive Escherichia coli and Shigellae. Journal of Medical Microbiology. 35: 330-337.
  • Hossain, A. Haider, K., Huq, M.I. and Zaman, A. (1988). Studies on the factors affecting the production of hemolysin by Vibrio mimicus isolated from clinical and environmental sources. Transactions of the Royal Society of Tropical Medicine and Hygiene. 82: 337-339.
Novel Gene Identification
  • GenBank Accession number AY780674 Hossain,A., Buck,L., Moland,E.S., Thomson,K.S. and Hanson,N.D. (2004). Pseudomonas aeruginosa IMP-18 (IMP-18) gene, complete sequenceGenBank Accession Number AY324388.
  • Hossain, A., Reisbig,M.D. and Hanson,N.D. (2004). Salmonella typhimurium plasmid pSal-100 putative TraA protein and beta- lactamase CMY-7 (blaCMY-7) genes, complete sequence.
  • GenBank Accession Number AY034847. Moland,E.S.,
  • Hanson,N.D., Herrera,V.L., Black,J.A., Lockhart,T.J.,
  • Hossain,A., Johnson,J.A., Goering,R.V. and Thomson,K.S. (2003). Klebsiella pneumoniae carbapenemase (KPC-2) gene, complete sequence.
Conferences/Workshops
Conference Presentations / Abstracts
  1. Hassan, M. A, Ruba, Mukhtar Iqra, Mohamed, E. M. Manar, Aya Khalid Sayed Aly Ibrahim, K. S. Aya, Magaogao, Michael; Ali Afsar and Ashfaque Hossain (2017) Carriage of antibiotic resistant, biofilm producing bacteria on currency notes and coins of United Arab Emirate (UAE). 117th American Society for Microbiology Conference. June 1-5, 2017. New Orleans, USA.
  2. Mohammed AlMogbel, Ibraheem Alshankety, Fawaz AlRashid, Abrar Ali Katpar, Ashfaque Hossain, Afaq Gowhar, Godfred Menezes, Mushtaq Khan (2016). Characterization of Staphylococcus aureus isolated from a renal hemodialysis (HD) patients. 26th ECCMID; April 9-12, 2016. Amsterdam, Netherlands.
  3. Marzooq Moottlaq, Alshammary Aljammen, Mutlaq Fahed Alshammari, Jamal Mohammad Arif, Ashfaque Hossain, Syed Monowar Alam Shahid, Mohd Adnan Kausar (2015). Assessment of bacteriological quality of indoor air in different hospitals of Hail region, KSA. 3rd Middle East� Asia Allergy Asthma Immunology Congress.,11-13 December, 2015 in Abu Dhabi, United Arab Emirates.
  4. Al-Harbi, M. A. R., Al-Atiq, A. A. R., Al-Ateeq, A., Mayor, L. B., Fazaludeen, M. ., Khan, M., Al-Mogbel, M. S., Ali, A. and Hossain, A. (2015). Gain of resistance to cefoxitin leads to enhanced biofilm production by Klebsiella pneumonia. 115th American Society for Microbiology Conference, May29-31, New Orleans, USA.
  5. Alshammari, N. R. R., Alshammari N. K. A., Alshammari, F. S. M., Alshammari, F. A., Alswaida, M. S. M., Beg, Q. B., Hassan, A. B., Ginawi, I., Al-Hazimi, A., Al-Mogbel, M. S., Ali, A. and Hossain, A. (2014). Growth in biofilm modulates the potential to form new biofilm by Staphylococcus Aureus. 114th American Society for Microbiology Conference, May 18-20, Boston, USA.
  6. Al-Marshedy, S., Al-Tamini, N., Fatima, S. S., Yasmin, T., Hazimi, A;, Talukdar, P.K. Sarker, M. and Hossain, A. (2012). Investigation on biofilm production by nasal isolates of Staphylococcus aureus. 112th American Society for Microbiology Conference, June 16-18, San Francisco, USA.
  7. Hossain, A. Shadeed, M.., Hazimi, A. and Mogbil, M. (2010). Production of biofilm by fresh clinical strains of Pseudomonas aeruginosa isolated in hail, Saudi Arabia. 2nd International Conference on Advancement in Science and Technology, Kuantan, Malaysia.
  8. Hossain, A. and L.K. Jung (2007). Expression of bone specific alkaline phosphatase on human B cell. J. Immunol. (meeting abstract), 178, 68.18
  9. Pitout, J. D. D., Hossain, A., Church, D. L. and Hanson, N. D. (2004). Laboratory Diagnosis of Escherichia coli and Klebsiella spp. producing CTX-M-�-lactamases. American Society for Microbiology, 104nd General Meeting, New Orleans.
  10. Lister, P. D., Hossain, A., Black, J., Moland, E. S. and Hanson, N. D. (2004). Fluoroquinolone selected resistance among Pseudomonas aeruginosa: impact on susceptibility to imipenem, ertapenem and meropenem. 14th European Congress on Clinical Microbiology and Infectious Diseases. Prague, Czech Republic.
  11. Moland, E. S., Lockhart, T. J., Black, J. A., Olson, L. B. Hossain, A., Hanson, N. D. and Thompson, K. S. (2004). Evaluation of cefepime with and without clavulanic acid for the detection of extended spectrum ?-lactamases in Enterobacteriaceae. 14th European Congress on Clinical Microbiology and Infectious Diseases. Prague, Chez Republic.
  12. Hossain, A., Ferraro, M. J., Pino, R. M., Dew, R. B., Moland, E. S., Lockhart, T. J., Thomson, K. S., Goering, R. V. and Hanson, N. D. (2003). First report of plasmid encoded carbapenem hydrolyzing enzyme KPC-2 in Enterobacter cloacae. 43nd Interscience conference on antimicrobial agents and chemotherapy. Chicago.
  13. Moland, E. S., Sharp, S. E., Suarez, C., Hossain, A., Hanson, N. D. and Thompson, K. S. (2003). Occurrence of a CTX-M-1-like ESBL in US isolates of Citrobacter freundii. 43nd Interscience conference on antimicrobial agents and chemotherapy. Chicago.
  14. Moland, E. S., Black, J. A., Hanson, N. D., Hossain, A., Abdalhamid, B. Song, W., Lockhart, T. J., Olson, L. B. and Thompson, K. S. (2003). Prevalence of ESBLs in the United States. 43nd Interscience conference on antimicrobial agents and chemotherapy.
  15. Moland, E. S., Black, J. A., Thompson, K. S., Hanson, N. D., Lockhart, T. J., Olson, L. B. and Hossain, A. (2003). Detection of CTX-M-like ESBLs in thirteen states within USA. 43nd Interscience conference on antimicrobial agents and chemotherapy. Chicago.
  16. Black, J. A., Moland, E. S., Hossain, A., Lockhart, T. J., Olson, L. B. Thompson, K. S., and Hanson, N. D. (2003). Prevalence of plasmid mediated ampC ?-lactamases in Klebsiella pneumoniae, Proteus mirabilis and Salmonella isolates from 42 ICU and 21 non-ICU sites in the United States. 43nd Interscience conference on antimicrobial agents and chemotherapy. Chicago.
  17. Hossain, A., Wickman, P. and Hanson, N. D. (2003).Molecular analysis of Streptococcus pneumoniae mutants selected by DK-507k. an investigational fluoroquinolone. 13th European Congress on Clinical Microbiology and Infectious Diseases. Glasgow, U.K
  18. Hossain, A., Reisbig, M.D., and Hanson, N. D. (2003). High level expression of the plasmid encoded AmpC gene blaCMY-7 does not compromise the virulent phenotype of a strain of Salmonella typhimurium. 13th European Congress on Clinical Microbiology and Infectious Diseases. Glasgow, U.K.
  19. Lister, P. D. and Hossain, A. (2003). Post-antibiotic effect studies with a new fluoroquinolone DK-507k and 6 other fluoroquinolones. 13th European Congress on Clinical Microbiology and Infectious Diseases. Glasgow, U.K.
  20. Wickman, P., Hossain, A., Thompson, K.S and Hanson, N. D. (2003). Differences in selection of efflux-mediated fluoroquinolone resistance in penicillin-susceptible and resistant Streptococcus pneumoniae after repeated exposure to ciprofloxacin and moxifloxacin. 13th European Congress on Clinical Microbiology
  21. Wickman, P. Hossain, A., Thompson, K.S and Hanson, N. D. (2002). Moxifloxacin has reduced potential to select for mutational fluoroquinolone resistance in Streptococcus pneumoniae. American Society for Microbiology, 102nd General Meeting, Salt lake City.
  22. Hossain, A., Moland, E.S., Black, J.A., Hanson, N.D. and Thompson, K.S. (2002). In vitro development and mutational resistance analysis in Staphylococcus aureus, penicillin resistant Streptococcus pneumoniae and vancomycin resistant enterococci. 42nd Interscience conference on antimicrobial agents and chemotherapy, San Diego.
  23. Hossain, A., Moland, E.S., Black, J.A., Chartrand, S.A., Hanson, N.D. and Thompson, K.S. (2001). DQ-113: A new fluoroquinolone with low frequency of mutational resistance in MRSA. 41st Interscience conference on antimicrobial agents and chemotherapy, Chicago.
  24. Hanson, N.D., Neville, S.A., Gosbell, I.B., Hossain, A., Moland, E.S. and Thompson, K.S. (2001). Salmonella enterica serotype Typhimurium producing CMY-7, SHV-9 and OXA-30 beta- lactamases. 41st Interscience conference on antimicrobial agents and chemotherapy, Chicago.
  25. Moland, E.S., Johnson, J., Black, J., Lockhart, T.J., Hossain, A., Hettera,V, L., Hanson, N.D. and Thompson, K.S. (2001). Klebsiella pneumoniae isolates producing a carbapenem hydrolyzing enzyme. 41st Interscience conference on antimicrobial agents and chemotherapy, Chicago.
  26. Haider, K., Hossain, A., Beattie, D. T., Spofford, K. H., Doidge, C. and Killeen, K. (1998). Cloning and characterization of Helicobacter pylori carbohydrate antigens. American Society for Microbiology. 98th General Meeting, Atlanta, Georgia.
  27. Hossain, A., Schang, L.M., Holt, T. and Jones, C. (1996). Interaction of latency related protein of bovine herpes virus type 1 (BHV-1) with mammalian cell cycle. 21st International Herpes virus congress. University of Northern Illinois, Dekalb, Illinois.
  28. Hossain, A., Schang, L.M., and Jones, C. (1996). Functional analysis of the latency related protein of bovine herpes virus 1 (BHV-1). American Society for Microbiology Missouri Valley Branch Annual Meeting, Creighton University, Omaha, Nebraska.
  29. Schang, L.M, Hossain, A, and Jones, C. (1995). The latency related gene of bovine herpes virus type 1 (BHV-1) encodes a factor which inhibits mammalian cell cycle progression. 20th International herpes virus congress. University of Groningen, Groningen, The Netherlands.
  30. Schang, L.M, Hossain, A, and Jones, C. (1995). The latency related gene of bovine herpes virus type 1 can be involved in neuronal survival during infection. 76th Annual Meeting of the Conference of Research Workers in Animal Diseases, Chicago.
  31. Hossain, A., Schang, L.M., and Jones, C. (1994). Analysis of latency related gene products (protein) from bovine herpes virus type 1. 19th International Herpes Virus Congress. University of British Columbia Vancouver, Canada.
  32. Schang, L.M, Hossain, A, and Jones, C. (1994). Analysis of latency related gene products (RNA) from bovine herpes virus type 1. 19th International Herpes Virus Congress. University of British Columbia, Vancouver, Canada.
  33. Hossain, A. and Stewart-Tull, D.E.S. (1991). Virulence of Campylobacter jejuni: correlation between in vitro and in vivo assays. Commonwealth Conference on Diarrhea and malnutrition. New Delhi, India.