TMRC offers a comprehensive, end-to-end in vitro research ecosystem supporting discovery, validation, and mechanistic understanding under one integrated framework.

In Vitro Non-Biological Testing Laboratory (TMRC–701)

TMRC–701 is a high-end analytical and formulation facility supporting pharmaceutical sciences, nanotechnology, materials science, and chemical analysis.

Core Capabilities

• Design and development of advanced nano- and micro-formulations using diverse biopolymers
• Particle size distribution, stability profiling, and physicochemical characterization
• High-resolution chemical, structural, and thermal analyses
• Phytoconstituent profiling, impurity assessment, pesticide detection, and ultra-trace quantification

Key Instrumentation

• Waters Xevo TQ-XS Tandem Quadrupole Mass Spectrometer (ultra-trace analysis)
• Automated and Manual HPLC Systems
• Flash Chromatography System
• Nano Generator (Precigenome, USA)
• Particle Size Analyzer
• FTIR and UV–Visible Spectrophotometers
• Differential Scanning Calorimeter (DSC)
• Freeze Dryer

Technical Support: Mr. Mohammad Quamrul Islam, Ms. Aida Ruzzana Binti Ghafar

In Vitro Biological Testing Laboratory (TMRC–709)

TMRC–709 functions as a multidisciplinary translational research hub integrating biological, molecular, and omics platforms within a single, cohesive environment.

Microbiology Unit

• Repository of bacterial and fungal strains
• Antimicrobial susceptibility and microbial interaction studies
• Biocompatibility assessment of novel compounds and biomaterials

Cell Culture Unit

• Extensive panel of human and murine normal, cancer, and primary cell lines
• Cancer models: breast, lung, cervical, hepatic, and colorectal
• Normal and primary cells including epithelial, fibroblast, and stem cell systems
• Cytotoxicity, mechanistic, pathway-based, and therapeutic screening

Molecular Biology Unit

• RT-PCR and qRT-PCR platforms for qualitative and quantitative gene expression analysis
• Nucleic acid extraction, quantification, and electrophoretic workflows
• Evaluation of molecular signaling pathways and target modulation

Next Generation Sequencing (NGS) Unit

• MinION Mk1D Nanopore Sequencing System
• MiniSeq (Illumina) short-read sequencing platform
• PromethION Solo: large-scale long-read DNA and RNA sequencing
• In-house whole genome sequencing, transcriptomics, epigenetics, and structural variant analysis
• Dedicated sequencing and bioinformatics support under defined frameworks

Biochemistry & Immunology Unit

• Fully automated biochemistry analyzer supporting 95+ test parameters
• Comprehensive metabolic, inflammatory, immunological, and biomarker panels
• ELISA-based quantitative biomarker estimation
• Body mass composition analysis

Histopathology Unit

• Automated tissue processing and embedding systems
• Microtome and high-resolution digital microscopy
• Routine and special stains including H&E and Masson’s Trichrome

Technical Support: Ms. Sheela Haridas, Mr. Michael V. Magaogao, Ms. Shatha Nayef Mahd Abdel Jaber

Activities

• High-impact translational research projects
• Drug discovery and target validation studies
• Biomarker discovery and diagnostic research
• Skill-based training programs and workshops
• National and international collaborative research initiatives